image showing molecular structure

Section of Experimental Oncology

2007 Publications

Brownhill, S; Taylor, C; Burchill, S.A 2007 Chromosome 9p21 gene copy number detected by mlpa and prognostic significance of p16 and p14arf in esft. British Journal of Cancer, 96: 1914-23

Bruning-Richardson, A; Morrison, E.E 2007 The adenomatous polyposis coli tumor suppressor protein and microtubule dynamics. Current Colorectal Cancer Reports, 3: 82-6

Chapman, E; Hurst, C; Pitt, E; Chambers, P; Aveyard, J; Knowles, M 2007 Expression of hTERT Immortalises Normal Human Urothelial Cells without Inactivation of the p16/Rb Pathway. Oncogene, 25: 5037-45

Dyrskjot, L; Zieger, K; Real, F.X; Malats, N; Carrato, A; Hurst, C; Kotwal, S; Knowles, M; Malmstrom, P.U; de la Torre M; Wester, K; Allory, Y; Vordos, D; Caillault, A; Radvanyi, F; Hein, A.M; Jensen, J.L; Jensen, K.M; Marcussen, N; Orntoft, T.F 2007 Gene expression signatures predict outcome in non-muscle-invasive bladder carcinoma: A Multicenter Validation Study. Clinical Cancer Research, 13: 3545-51

Harnden, P; Shelley, M.D; Clements, H; Coles, B; Tyndale-Biscoe, R.A; Naylor, B; Mason, M.D 2007 The prognostic significance of perineural invasion in prostatic cancer biopsies. A systematic review. Cancer, 109: 13-24

Harnden, P; Shelley, M.D; Coles, B; Staffurth, J; Mason, M.D 2007 Should the Gleason Grading system for Prostate cancer be modified to account for high grade tertiary patterns? A systematic review and meta-analysis. Lancet Oncology, 8: 411-9

Harnden, P 2007 A critical appraisal of the classification of urothelial tumours: time for a review of the evidence and a radical change? BJU International, 99: 723-5

Hurst, C; Tomlinson, D.C; Williams, S.V; Platt, F.M; Knowles, M.A 2007 Inactivation of Rb pathway and overexpression of the E2F3a isoform are obligate events in bladder tumour with 6p22 amplification Oncogene, [Epub 26.11.07]

Knowles, M.A 2007 Tumor suppressor loci in bladder cancer. Frontiers in Bioscience, 12: 2233-51

Knowles, M.A 2007 Role of FGFR3 in urothelial cell carcinoma: biomarker and potential therapeutic target. World J Urol, 25: 581-93

Kotwal, S; Choudhury, A; Johnston, C; Paul, A.B; Whelan, P; Kiltie, A.E 2007 Similar treatment outcomes for radical cystectomy and radical radiotherapy in invasive bladder cancer treated at a UK specialist treatment centre International Journal of Radiation Oncology Biology and Physics, [Epub 26.9.07]

Lastowska, M; Viprey, V; Santibanez-Koref, M; Wappler, I; Peters, H; Cullinane, C; Roberts, P; Hall, A.G; Tweddle, D.A; Pearson, A.D; Lewis, I; Burchill, S.A; Jackson, M.S 2007 Identification of candidate genes involved in neuroblastoma progression by combining genomic and expression microarrays with survival data. Oncogene, 26: 7432-74

Lee, T; Langford, K.J; Askham, J.M; Brüning-Richardson, A; Morrison, E.E 2007 MCAK associates with EB1 Oncogene, [Epub 29.10.07]

Morrison, E.E 2007 Action and interactions at microtubule ends. Cellular and Molecular Life Sciences, 64: 307-17

Myatt, S.S; Burchill, S.A 2007 The sensitivity of the Ewing’s sarcoma family of tumours to fenretinide-induced cell death is increased by EWS-Fli1 dependent modulation of p38MAPK activity. Oncogene, [Epub 13.11.07]

Neveling, K; Kalb, R; Florl, A.R; Herterich, S; Friedl, R; Hoehn, H; Hader, C; Hartmann, F.H; Nanda, I; Steinlein, C; Schmid, M; Tonnies, H; Hurst, C; Knowles, M.A; Hanenberg, H; Schulz, W.A; Schindler, D 2007 Disruption of the FA/BRCA pathway in bladder cancer. Cytogenet Genome Res, 118: 166-76

Roberts, P; Burchill, S.A; Brownhill, S; Cullinane, C.J; Johnston, C; Griffiths, M.J; McMullan, D.J; Bown, N.P; Morris, S.P; Lewis, I.J 2007 Ploidy and karyotype complexity are powerful prognostic indicators in the Ewing’s sarcoma family of tumours: A study by Children’s Cancer and Leukaemia Group. Genes, Chromosomes Cancer, [Epub 6.12.07]

Sak, S.C; Barrett, J.H; Paul, A.B; Bishop, T.D; Kiltie, A.E 2007 DNA repair gene XRCC1 polymorphisms and bladder cancer risk. BMC Genetics, 8: 13

Tomlinson, D.C; Hurst, C.D; Knowles, M.A 2007 Knockdown by shRNA identifies mutant FGFR3 as a potential therapeutic target in bladder cancer. Oncogene 26:5889-99

Tomlinson, D.C; Baldo, O; Harnden, P; Knowles, M.A 2007 FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer. J Pathol, 13: 91-8

Viprey, V.F; Corrias, M.V; Kageda, B; Oltra, S; Swerts, K; Vicha, A; Ladenstein, R; Burchill, S.A 2007 Standardisation of operating procedures for detection of minimal disease by QRT-PCR in children with neuroblastoma; quality assurance on behalf of SIOPEN-R-NET. European Journal Cancer; 43:341-50

2008 Publications

Bentley, J; L’Hote, C; Platt, F; Hurst, C.D; Lowery, J; Taylor, C; Harnden, P; Sak, S.C; Knowles, M.A; Kiltie, A.E. 2008 Differences in end-joining fidelity in human bladder cancer are associated with reduced Ku activity and altered p53 function. Genes Chromosomes and Cancer doi 10.1002/gcc.20641

Bentley, J; L'Hote, C; Platt, F; et al. 2008 Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities. Genes Chromosomes Cancer

Burchill, S.A. 2008 Molecular abnormalities in Ewing's sarcoma. Expert Rev Anticancer Ther 8(10):1675-1687

Chatzimeletiou, K; Morrison, E.E; Prapas, N; Prapas, Y; Handyside, A.H 2008 The centrosome and early embryogenesis: clinical insights. Reprod Biomed Online 16(4):485-91

Choudhury, A; Elliott, F; Iles, M.M; Churchman, M; Bristow, R.G; Bishop, D.T; Kiltie, A.E. 2008 Analysis of variants in DNA damage signalling genes in bladder cancer. BMC Med Genet 9: 69

Dunn, S; Morrison, E.E; Liverpool, T; Carmen, M-P; Cross, R.A; Alonso, M.C; et al 2008 Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells. Journal of Cell Science 121:1085-95

Hurst, C.D; Tomlinson, D.C; Williams, S.V; Platt, F.M; Knowles, M.A 2008 Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification. Oncogene 27(19):2716-2727

Karam, J.A; Shahrokh, F; Hsieh, J-T; Knowles, M.A. 2008 Genomics: a preview of genomic medicine. BJU International 102:1221-1227

Kiemeney, L.A; Thorlacius, S; Sulem, P; Geller, G; Aben, K.K.H; Stacey, S.N; Gudmundsson, J; Jakobsdottir, M; Bergthorsson, J.T; Sigurdsson, A; Blondal, T; Witjes, J.A; Vermeulen, S.H; Hulsbergen-van de Kaa, C.A; Swinkels, D.W; Ploeg, M; Cornel, E.B; Vergunst, H; Thorgeirsson, T.E; Gudbjartsson, D; Gudjonsson, S.A; Thorleifsson, G; Kristinsson, K.T; Mouy, M; Snorradottir, S; Placidi, D; Campagna, M; Arici, C; Koppova, K; Gurzau, E; Rudnai, P; Kellen, E; Polidoro, S; Guarrera, S; Sacerdote, C; Sanchez, M; Saez, B; Valdivia, G; Ryk, C; de Verdier, P; Lindblom, A; Golka, K; Bishop, D.T; Knowles, M.A; Nikulasson, S; Petursdottir, V; Jonsson, E; Geirsson, G; Kristjansson, B; Mayordomo, J.I; Steineck, G; Porru, S; Buntinx, F; Zeegers, M.P; Fletcher, T; Kumar, R; Matullo, G; Vineis, P; Kiltie, A.E; Gulcher, J.R; Thorsteinsdottir, U; Kong, A; Rafnar, T; Stefansson, K. 2008 Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Nature Genetics 40:1307-1312

Kiltie, A.E; Choudhury, A; Johnston, C; Kotwal, S; Paul, A.B; Whelan, P. 2008 In reply to Rosario et al. Int J Radiation Oncol Biol Phys 71:1602

Knowles, M.A 2008 Molecular pathogenesis of bladder cancer. Int J Clin Oncol 13:287-297

Knowles, M.A 2008 Novel therapeutic targets in bladder cancer: mutation and expression of FGF receptors. Future Oncol Feb;4(1):71-83

Knowles, M.A 2008 Bladder cancer subtypes defined by genomic alterations. Scand J Urol Nephrol Suppl 218:116-130

Kotwal, S; Choudhury, A; Johnston, C; Paul, A.B; Whelan, P; Kiltie, A.E 2008 Similar treatment outcomes for radical cystectomy and radical radiotherapy in invasive bladder cancer treated at a UK specialist treatment centre International Journal of Radiation Oncology Biology and Physics 70:456-63

Magwere, T; Myatt, S.S; Burchill, S.A. 2008 Manipulation of oxidative stress to induce cell death in Ewing's sarcoma family of tumours. Eur J Cancer 44(15):2276-2287

Myatt, S.S; Burchill, S.A 2008 The sensitivity of the Ewing’s sarcoma family of tumours to fenretinide-induced cell death is increased by  EWS-Fli1 dependent modulation of p38MAPK activity. Oncogene 27: 985-96

Pymar, L; Platt, F; Askham, J; Morrison, E; Knowles, M.A 2008 Bladder tumour derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms. Human Molecular Genetics

Roberts, P; Burchill, S.A; Brownhill, S; Cullinane, C.J; Johnston, C; Griffiths, M.J; Mcallum, D; Brown, N; Morris, S.P; Lewis, I.J 2008 Ploidy and karyotype complexity are powerful prognostic indicators in the Ewing’s sarcoma family of tumours: A study by Children’s Cancer and Leukaemia Group. Genes, Chromosomes and Cancer 47:207-20

Viprey, V.F; Lastowska, M.A; Corrias, M.V; Swerts, K; Jackson, M.S; Burchill, S.A. 2008 Minimal disease monitoring by QRT-PCR: guidelines for identification and systematic validation of molecular markers prior to evaluation in prospective clinical trials. J Pathol 216(2):245-252

White, D.E; Burchill, S.A. 2008 BAY 11-7082 induces cell death through NF-kappaB-independent mechanisms in the Ewing's sarcoma family of tumours. Cancer Lett 268(2):212-224

Zhou, J; Zhang, X.Q; Ashoori, F; et al.2008 Early RB94-produced cytotoxicity in cancer cells is independent of caspase activation or 50 kb DNA fragmentation. Cancer Gene Ther