Elucidation of the molecular basis of carcinogenesis in the gastrointestinal tract is vital for development of novel therapeutic strategies for prevention and treatment of common malignancies such as colorectal and stomach cancer. Research in the Section of Molecular Gastroenterology is focussed on several important pro-tumorigenic pathways, which each represent a promising therapeutic anti-cancer target. One general theme is investigation of the molecular basis of the consistent link between chronic inflammation and development of cancer along the whole length of the gastro-intestinal tract. Individual research areas include the role of eicosanoids, cytokines, receptor tyrosine kinase signalling and pro-angiogenic factors during tumorigenesis in the upper and lower gastrointestinal tract. Research Groups use a wide range of in vitro and in vivo cancer models, as well as human tissue expression and biomarker studies, with a view to translation of novel molecular insights into early clinical studies of novel anti-cancer agents.