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Section of Molecular Gastroenterology

2012 Publications

Chan AT, Arber N, Burn J, Chia W-K, Elwood P, Hull MA, Logan RF, Rothwell PM, Schrör K, Baron JA (2012) Aspirin in the chemoprevention of colorectal neoplasia: An overview. Cancer Prev Res, in press

Cockbain AJ, Toogood GJ, Hull MA (2012) Omega-3 polyunsaturated fatty acids for the prevention and treatment of colorectal cancer. Gut 61, 135-49

Hull MA, Yainnakou Y, Gower J, Ryder SD, Bloom S, Rees C (2012) Getting involved in Clinical Trials Research in the United Kingdom: How can Clinical Research Networks help? Frontline Gastroenterol, in press

Lee TJW, Hull MA, Rajasekhar P, Clifford GM, Ritchie M, James P, McNally RJQ, Rutter MD, Rees CJ (2012) Aspirin users attending for NHS bowel cancer screening have less colorectal neoplasia:  Chemoprevention or false-positive faecal occult blood testing? Digestion, in press

Marsh L, Coletta PL, Hull MA, Selby PJ, Carding SR (2012) Altered intestinal epithelium-associated lymphocyte repertoires and function in ApcMin/+ mice. Int J Oncol 40, 243-50

Suares NC, Hamlin PJ, Greer DP, Warren L, Clark T, Ford AC (2012) Efficacy and tolerability of methotrexate for refractory Crohn’s disease: A large single-centre experience. Aliment Pharmacol Ther 35, 284-91

2011 Publications

Ford AC, Sandborn WJ, Khan KJ, Hanauer SB, Talley NJ, Moayyedi P (2011) Efficacy of biological therapies in inflammatory bowel disease: Systematic review and meta-analysis. Am J Gastroenterol 106, 644-59

Ford AC, Kane SV, Khan KJ, Achkar J-P, Talley NJ, Marshall JK, Moayyedi P (2011) Efficacy of 5-aminosalicylates in Crohn’s disease: Systematic review and meta-analysis. Am J Gastroenterol 106, 617-29

Ford AC, Achkar J-P, Khan KJ, Kane SV, Talley NJ, Marshall JK, Moayyedi P (2011) Efficacy of 5-aminosalicylates in ulcerative colitis: Systematic review and meta-analysis. Am J Gastroenterol 106, 601-16

Ford AC, Bernstein CN, Khan KJ, Abreu MT, Marshall JK, Talley NJ, Moayyedi P (2011) Glucocorticosteroid therapy in inflammatory bowel disease: Systematic review and meta-analysis. Am J Gastroenterol 106, 590-599

Ford AC, Khan KJ, Talley NJ, Moayyedi P (2011) 5-aminosalicylates prevent relapse of Crohn’s disease after surgically-induced remission: Systematic review and meta-analysis. Am J Gastroenterol 106, 413-20

Ford AC, Suares NC (2011) Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: Systematic review and meta-analysis. Gut 60, 209-18

Ford AC, Suares NC, Talley NJ (2011) Epidemiology of non-cardiac chest pain in the community: Systematic review and meta-analysis. Aliment Pharmacol Ther 34, 172-80

Ford AC, Khan KJ, Sandborn WJ, Kane SV, Moayyedi P (2011) Once-daily dosing versus conventional dosing schedule of mesalamine and relapse of quiescent ulcerative colitis: Systematic review and meta-analysis. Am J Gastroenterol 106, 2070-7

Hogan BV, Peter MB, Shenoy H, Horgan K, Hughes TA (2011) Surgery induced immunosuppression. Surgeon 9, 38-43

Hogan BV, Peter MB, Achuthan R, Beaumont A, Langlands F, Shakes S, Wood P, Shenoy H, Orsi N, Horgan K, Carter CR, Hughes TA (2011) Peri-operative reductions in circulating lymphocyte levels predict wound complications after excisional breast cancer surgery. Annals Surgery 253, 360-4

Hull MA (2011) Omega-3 polyunsaturated fatty acids in Chemoprevention in Gastroenterology. Best Practice & Res Clin Gastroenterology 25, 547-54

Kant P, Hull MA (2011) Excess body weight and obesity - the link with gastrointestinal and hepatobiliary cancer. Nature Rev Gastroenterol Hepatol 8, 224-38

Kant P, Sainsbury A, Reed KR, Pollard SG, Scott N, Clarke AR. Coletta PL, Hull MA (2011) Rectal epithelial cell mitosis and expression of macrophage migration inhibitory factor are increased three years after Roux-en-Y gastric bypass (RYGB) for morbid obesity: Implications for long-term neoplastic risk following RYGB. Gut 60, 893-901

Khan KJ, Dubinsky MC, Ford AC, Ullman TA, Talley NJ, Moayyedi P (2011) Efficacy of immunosuppressive therapy for inflammatory bowel disease: A systematic review and meta-analysis. Am J Gastroenterol 106, 630-42

Khan KJ, Ullman TA, Ford AC, Abreu MT, Abadir A, Marshall JK, Talley NJ, Moayyedi P (2011) Antibiotic therapy in inflammatory bowel disease: A systematic review and meta-analysis. Am J Gastroenterol 106, 661-73

Macnab SA, Turrell SJ, Carr IM, Markham AF, Coletta PL, Whitehouse A (2011) Herpesvirus saimiri-mediated delivery of the adenomatous polyposis coli tumour suppressor gene reduces proliferation of colorectal cancer cells. Int J Oncol 39, 1173-81

Madhok BM, Yeluri S, Perry SL, Hughes TA, Jayne DG (2011) Targeting glucose metabolism: an emerging concept for anticancer therapy. Am J Clin Oncol 34, 628-35

Nicholson BD, Hyland R, Rembacken BJ, Denyer ME, Hull MA, Tolan DJM (2011) Colonoscopy for colonic wall thickening at CT: a worthwhile pursuit? Surg Endosc 25, 2586-91

Pakseresht M, Forman D,  Malekzadeh R, Greenwood D, Yazdanbod A, Jafarzadeh H,  Sadjadi A, Crabtree JE, Cade J. Dietary habits and gastric cancer risk in Northwest Iran. Cancer Causes and Control 2011; 22: 725-736.

Sainsbury A, Sanders DS, Ford AC (2011) Meta-analysis: Coeliac disease and hypertransaminasaemia. Aliment Pharmacol Ther 34, 33-40

Satheesha S, Cookson VJ, Coleman LJ, Ingram N, Madhok B, Hanby AM, Suleman CAB, Sabine VS, Macaskill EJ, Bartlett JMS, Dixon JM, McElwaine JN, Hughes TA (2011) Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer. Mol Cancer 10, 19

Sprakes MB, Hamlin PJ, Warren L, Greer D, Ford AC (2011) Adalimumab as a second line anti-tumour necrosis factor alpha therapy for Crohn’s disease: A single centre experience. J Crohn’s Colitis 5, 324-31

Suares NC, Ford AC (2011) Prevalence of, and risk factors for, chronic idiopathic constipation in the community: Systematic review and meta-analysis. Am J Gastroenterol 106, 1582-91

Verghese ET, Shenoy H, Cookson V, Green C, Howarth J, Partanen R, Pollock S, Waterworth A, Speirs V, Hughes TA, Hanby A (2011) Epithelial-mesenchymal interactions in breast cancer: evidence for a role of nuclear ?-catenin in carcinoma-associated fibroblasts. Histopath, 59, 609-18

2010 Publications

Al-Nakhle H, Burns P, Cummings M, Hanby A, Hughes TA, Satheesha S, Shaaban A, Smith L, Speirs V (2010) miR-92 Is a novel regulator of ERbeta1 expression in breast cancer. Cancer Res 70, 4778-84

Craig DGN, Ford AC, Hayes PC, Simpson KJ (2010) Systematic review and meta-analysis: Prognostic tests of paracetamol-induced acute liver failure. Aliment Pharmacol Ther 31, 1064-76

Ford AC, Marwaha A, Lim A, Moayyedi P (2010) What is the prevalence of clinically significant endoscopic findings in subjects with dyspepsia? Systematic review and meta-analysis. Clin Gastroenterol Hepatol 8, 830-37

Ford AC, Moayyedi P (2010) Meta-analysis: Factors affecting placebo response rate in irritable bowel syndrome. Aliment Pharmacol Ther 32, 144-58

Ford AC, Thabane M, Moayyedi P, Collins SM, Garg AX, Clark WF, Marshall JK (2010) Prevalence of uninvestigated dyspepsia 8 years after a large waterborne outbreak of bacterial dysentery: A cohort study. Gastroenterology 138, 1727-736

Ford AC, Guyatt GH, Talley NJ, Moayyedi P (2010) Errors in the conduct of systematic reviews of pharmacological interventions for irritable bowel syndrome. Am J Gastroenterol 105, 280-88

Ford AC, Marwaha A, Lim A, Moayyedi P (2010) Systematic review and meta-analysis of the prevalence of irritable bowel syndrome in individuals with dyspepsia. Clin Gastroenterol Hepatol 8, 401-9

FitzGerald RC, Hardwick R, Huntsman D, Carneiro F, Guilford P, Blair V, Chung DC, Norton J,Ragunath K, van Krieken JH, Dwerryhouse S, Caldas C and International Gastric Cancer Linkage Consortium (2010) Hereditary Diffuse Gastric Cancer: updated consensus guidelines for clinical management and directions of future research. J Med Genet 47, 436-44

Hawcroft G, Loadman PM, Belluzzi A, Hull MA (2010) The effect of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signalling in human colorectal cancer cells.
Neoplasia 12, 618-27

Lee G, Cama V, Gilman RH, Cabrera L, Saito M, Checkley W, the CONTENT Investigators. Comparison of two types of epidemiological surveys aimed at collecting daily symptoms in community-based longitudinal studies. Annals of Epidemiology 2010; 20: 151-158.

Madhok B, Yeluri S, Perry S, Hughes TA, Jayne D (2010) Dichloroacetate induces apoptosis and cell cycle arrest in colorectal cancer cells. Brit J Cancer 102, 1746-52

Moayyedi P, Ford AC, Talley NJ, Cremonini F, Foxx-Orenstein AE, Brandt LJ, Quigley EMM (2010) The efficacy of probiotics in the treatment of irritable bowel syndrome: A systematic review. Gut 59, 325-32

Smith L, Coleman LJ, Cummings M, Satheesha S, Shaw S, Speirs V, Hughes TA (2010) Expression of ER beta isoforms is regulated by transcriptional and post-transcriptional mechanisms. Biochem J 429, 283-290

Smith L, Brannan R, Hanby A, Shaaban A, Verghese ET, Peter M, Pollock S, Satheesha S, Szynkiewicz M, Speirs V, Hughes TA (2010) Expression of ER beta isoforms 1, 2 and 5 is differentially regulated by alternative 5’UTRs in cancer. J Cell Mol Med 14, 2172-8

Smith L, Speirs V, Hughes TA (2010) Estrogen receptor regulation: don't forget translation. Breast Can Res Treat 121, 251-2

Sprakes MB, Ford AC, Suares NC, Warren L, Greer D, Donnellan CF, Jennings JSR, Everett SM, Hamlin PJ (2010) Costs of care for Crohn’s disease following institution of infliximab: A single centre UK experience. Aliment Pharmacol Ther 32, 1357-63

West NJ, Clark SK, Phillips RK, Hutchinson JM, Leicester RJ, Belluzzi A, Hull MA (2010) Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis. Gut 59, 918-25

2009 Publications


Boxall SA, Cook GP, Pearce D, Bonnet D, El-Sherbiny YM, Blundell MP, Howe SJ, Leek JP, Markham AF, de Wynter EA (2009) Haemopoietic repopulating activity in human cord blood CD133+ quiescent cells. Bone Marrow Transplant 43, 627-635

Coleman LJ, Peter M, Teall T, Brannan R, Hanby AM, Honarpisheh H, Shaaban A, Smith L, Speirs V, Verghese ET, McElwaine J, Hughes TA (2009) Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity. Br J Cancer 100, 1393-9

Cuthbert RJ, Wilson JM, Scott N, Coletta PL, Hull MA (2009) Differential CD74 (major histocompatibility complex Class II invariant chain) expression in mouse and human intestinal adenomas. Eur J Cancer 45, 1654-63

de Wynter EA, Unwin R (2009) Wellcome Trust/EBI 2009 Meeting Report - Perspectives in Stem Cell Proteomics. Proteomics 9, 3630-4

Donnellan CF, Ford AC, Sprakes M, Greer D, Fairclough A, Warren L, Hamlin PJ (2009) Accelerated infliximab infusions are safe and well-tolerated in patients with inflammatory bowel disease. Eur J Gastroenterol Hepatol 21, 71-75

Evans CJ, Phillips RM, Jones PF, Loadman PM, Sleeman BD, Twelves CJ, Smye SW (2009) A mathematical model of doxorubicin penetration through multicellular layers. J Theor Biol 257, 598-608

Ford AC, Spiegel B, Talley NJ, Moayyedi P (2009) Small intestinal bacterial overgrowth in irritable bowel syndrome: Systematic review and meta-analysis. Clin Gastroenterol Hepatol 7, 1279-1286

Ford AC, Brandt LJ, Young C, Chey W, Foxx-Orenstein AE, Moayyedi P (2009) Efficacy of 5-HT3 antagonists and 5-HT4 agonists in irritable bowel syndrome: Systematic review and meta-analysis. Am J Gastroenterol 104, 1831-1843

Ford AC, Ching E, Moayyedi P (2009) Meta-analysis: Yield of diagnostic tests for coeliac disease in dyspepsia. Aliment Pharmacol Ther 30, 28-36

Ford AC, Chey WD, Talley NJ, Malhotra A, Spiegel B, Moayyedi P (2009) Yield of diagnostic tests for celiac disease in subjects with symptoms suggestive of irritable bowel syndrome: Systematic review and meta-analysis. Arch Int Med 169:651-658

Ford AC, Talley NJ, Schoenfeld P, Quigley EM, Moayyedi P (2009) Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: Systematic review and meta-analysis. Gut 58, 367-378

Hubbard M, Jones PF, Sleeman BD (2009) The Foundations of a Unified Approach to Mathematical Modelling of Angiogenesis. International J Adv Engin Sci App Math 1, 43–52

Meade JL, Wilson EB, Holmes TD, de Wynter EA, Brett P, Straszynski L, Ballard PA, Trapani JA, McDermott MF, Cook GP (2009) Proteolytic activation of the cytotoxic phenotype during human NK cell development. J Immunol 183, 803-13

Perry MD, Sandle GI (2009) Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin. Am J Physiol Gastrointest Liver Physiol 297, G159-67

2008 Publications

Burgoyne, C.H; Field, S.L; Brown, A.K; Hensor, L; Bingham, S.L; Verburg, R; Lawson, C.A; Hamlin, P.J; Straszinski, E; Maltby, S.L; Conaghan, P; Hull, M.A; van Laar, J.M; Tennant, A; Emery, P; Isaacs, J.D; Ponchel, F. 2008 Abnormal T-cell differentiation persists in rheumatoid arthritis patients in clinical remission and predicts relapse Ann Rheum Dis 67:750-757

Delaney B.C; Qume M; Moayyedi P; Logan R.F.A; Ford A.C; Elliot C; McNulty C; Wilson S; Hobbs F.D.R. 2008 Helicobacter pylori test and treat versus proton pump inhibitor in initial management of dyspepsia in primary care: Multi-centre randomised controlled trial (MRC-CUBE trial). Br Med J 336:651-654

Dzierzanowska-Fangrat, K; Michalkiewicz, J; Cielecka-Kuszyk, J; Nowak, M; Celinska-Cedro, D; Rozynek, E; Dzierzanowska, D; Crabtree, J.E. Enhanced gastric IL-18 mRNA expression in Helicobacter pylori infected children is associated with macrophage infiltration, IL-8, and IL-1 mRNA expression. European Journal of Gastroenterology and Hepatology 2008 20:314-319

Ford A.C; Malfertheiner P; Giguère M; Santana J; Khan M; Moayyedi P. 2008 Adverse events with bismuth salts for Helicbacter pylori eradication: Systematic review and meta-analysis. World J Gastroenterol 14:7361-7370

Ford A.C; Talley N.J; Spiegel B.M.R; Foxx-Orenstein A.E; Schiller L; Quigley E.M.M; Moayyedi P. 2008 Efficacy of fibre, antispasmodics, and peppermint oil in irritable bowel syndrome: Systematic review and meta-analysis. Br Med J 337:1388-1392

Ford A.C; Veldhuyzen van Zanten S.J.O; Rodgers C.C; Talley N.J; Vakil N.B; Moayyedi P. 2008 Diagnostic utility of alarm features for colorectal cancer: Systematic review and meta-analysis. Gut 57:1545-1553.

Ford A.C; Talley N.J; Veldhuyzen van Zanten S.J.O; Vakil N.B; Simel D.L; Moayyedi P. 2008 Rational clinical exam: Will the history and physical examination help establish that irritable bowel syndrome is causing this patient’s lower gastrointestinal tract symptoms? JAMA 300:1793-1805

Ford A.C; Forman D; Bailey A.G; Axon A.T.R; Moayyedi P. 2008 Fluctuation of gastrointestinal symptoms in the community: A 10-year longitudinal follow-up study. Aliment Pharmacol Ther 28:1013-1020

Ford A.C; Moayyedi P; Jarbol D.E; Logan R.F.A; Delaney B.C; 2008 Meta-analysis: H. pylori “test and treat” compared with empirical acid suppression for managing dyspepsia. Aliment Pharmacol Ther 28:534-544

Ford A.C; Forman D; Bailey A.G; Axon A.T.R; Moayyedi P. 2008 Irritable bowel syndrome: A 10-year natural history of symptoms, and factors that influence consultation behavior. Am J Gastroenterol 103:1229-1239

Hanby, A.M; Hughes, T.A 2008 In situ and invasive neoplasia of the breast. Histopath 52: 58-66

Hogan, B.V; Peter, M.B; Horgan, K; Hughes, T.A 2008 Circulating tumour cells in breast cancer: prognostic indicators, metastatic intermediates, or irrelevant bystanders? Mol Medicine Rep 1:775-779

Hughes, T.A; Jones, P.F 2008 Regulatory RNAs: Have mRNA untranslated regions joined the party? PLoS Med 5: 697-699

Hull M.A. 2008 Molecular pathways leading to cancer as a basis for preventative strategies. Curr Colorectal Cancer Rep 4: 43-47

Hull M.A. Bile acids and colorectal cancer. In: Bile Acids: Toxicology and Bioactivity, pp84-99. Jenkins G, Hardie L (eds.). RSC Publishing, Cambridge 2008

Jones, P.F; Sleeman, B.D. 2008 Mathematical Modelling of Avascular and Vascular Tumour Growth. Mathematical Methods in Scattering Theory and Biomedical Engineering 8:305-331

Ko, C.W.S; Cuthbert, R.J; Orsi, N.M; Brooke, D.A; Perry, S.L; Coletta, P.L; Hull, M.A. 2008 Lack of interleukin-4 receptor a chain-dependent signalling promotes azoxymethane-induced colonic aberrant crypt focus formation in Balb/c mice. J Pathol 214:603-609

Robins, G; Crabtree, JE; Bailey, A; Forman, D. 2008. International variation in Helicobacter pylori infection and histological subtype of oesophageal cancer. Eur J Cancer 44:726-32

Sainsbury, A; Goodlad, R.A; Perry, S.L; Pollard, S.G; Robins, G.G; Hull, M.A. 2008 Increased colorectal epithelial cell proliferation and crypt fission associated with obesity and Roux-en-Y gastric bypass Cancer Epidemiol Biomarkers Prev 17:1401-1410

Shaaban, A; Green, A; Karthik, S; Alizadeh, Y; Hughes, T.A; Harkins, L; Ellis, I; Robertson, J; Paish, E; Saunders, P; Groome, N; Speirs, V 2008 Nuclear and cytoplasmic expression of ERβ1, 2 and 5 identifies distinct outcomes for breast cancer patients. Clinical Cancer Res 14:5228-5235

Simon M; Duong J.P; Mallet V; Jian R; MacLennan K.A; Sandle G.I; Marteau P. 2008 Over-expression of colonic K+ channels associated with severe potassium secretory diarrhoea after haemorrhagic shock. Nephrol Dial Transplant 23:3350-2

Speirs, V; Green, A.R; Hughes, T.A; Ellis, I.O; Saunders, P.T; Shaaban, A.M. 2008 Clinical importance of estrogen receptor beta isoforms in breast cancer J Clin Oncol 26:5825

Verghese, E.T; Speirs, V; Hanby, A.M; Hughes, T.A 2008 Small is beautiful: microRNAs and breast cancer - where are we now? J Pathol 215: 214-221

Walker, M.S; Hughes, T.A 2008 Messenger RNA expression profiling using DNA microarray technology: diagnostic tool, scientific analysis or un-interpretable data? Int J Mol Med 21: 13-17