image showing molecular structure

 

Section of Pathology and Tumour Biology

2011 Publications

Ali M, Hocking PM, McKibbin M, Finnegan S, Shires M, Poulter JA, Prescott K, Booth A, Raashid Y, Jafri H, Ruddle JB, Mackey DA, Jacobson SG, Toomes C, Lester DH, Burt DW, Curry WJ, Inglehearn CF.Mpdz null allele in an avian model of retinal degeneration and mutations in human leber congenital amaurosis and retinitis pigmentosa Vis Sci. 2011 Sep 27;52(10):7432-40.

Brosens RP, Belt EJ, Haan JC, Buffart TE, Carvalho B, Grabsch H, Quirke P, Cuesta MA, Engel AF, Ylstra B, Meijer GA. Deletion of chromosome 4q predicts outcome in Stage II colon cancer patients. Cell Oncol (Dordr). 34(3):215-23

Buffart TE, Louw M, Grieken N CT, Tijssen M, Carvalho B, Ylstra B, Grabsh H, Mulder C JJ, Velde, CJH, Meijer, GA Gastric cancers of Western European and African patients show different patterns of genomic instability. BMC Medical Genomics

Collinson F, Jayne DG, Pigazzi A, Tsang C, Barrie J, Edlin R, Garbett C, Gullou P, Holloway I, Howard H, Marshall H, McCabe C, Pavitt S, Quirke P, Rivers CS, Brown JMB An International, multicentre, prospective, randomised, controlled, unblended, parallel-group trial of robotic-assisted versus standard laparoscopic surgery for the curative treatment of rectal cancer Springer-Verlag 2011

Dighe S, Swift I, Magill L, Handley K, Gray R, Quirke P, Morton D, Seymour M, Warren B, Brown G. Accuracy of radiological staging in identifying high-risk colon cancer patients suitable for neoadjuvant chemotherapy: a multicentre experience. Colorectal Dis. doi: 10.1111/j.1463-1318.2011.02638

Glimelius B, Beets-Tan R, Blomqvist L, Brown G, Nagtegaal I, Påhlman L, Quirke P, Valentini V, van de Velde C. Mesorectal fascia instead of circumferential resection margin in preoperative staging of rectal cancer. J Clin Oncol. 29(16):2142-3.

Logan CV, Lucke B, Pottinger C, Abdelhamed ZA, Parry DA, Szymanska K, Diggle CP, Riesen A, Morgan JE, Markham G, Ellis I, Manzur AY, Markham AF, Shires M, Helliwell T, Scoto M, Hübner C, Bonthron DT, Taylor GR, Sheridan E, Muntoni F, Carr IM, Schuelke M, Johnson CA. Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD) Nat Genet. 2011 Nov 20;43(12):1189-92. doi: 10.1038/ng.995

R Gray, P Quirke, K Handley, L Magill, C Beaumont, and David Kerr on behalf of the QUASAR Validation study of a quantitative multi-gene RT-PCR assay as a predictor of recurrence in stage II colon cancer patients doi 10.1200/JCO 2010.32.8732

Guan P, Wang M, Schlaberg HI, Khan JI, Speirs V Towards a-scan imaging via Ultrasonic Vibration Potential measurements. Nuc Eng Design 2011; 241: 1994–1997

Horimoto Y, Hartman J, Millour J, Pollock S, Olmos Y, Ho K-K, Coombes RC, Poutanen M, Mäkelä SI, El-Bahrawy M, Speirs V, Lam EWF ERβ1 represses FOXM1 expression through targeting  ERα to control cell proliferation in breast cancer. Am J Pathol 2011; 179:1148-1156

Haan JC, Buffart TE, Eijk PP, van de Wiel MA, van Wieringen WN, Howdle PD, Mulder CJ, van de Velde CJ, Quirke P, Nagtegaal ID, van Grieken NC, Grabsch H, Meijer GA, Ylstra B Small bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers. Ann Oncol. [Epub ahead of print]

Holliday DL, Speirs V Choosing the right cell line for breast cancer research. Breast Cancer Res 2011; 13:215-221

Horimoto Y, Hartman J, Millour J, Pollock S, Olmos Y, Ho K, Coombes C, Poutanen M, Makela S, El-Bahrawy M,
Speirs V, Lam E ERβ1 Represses FOXM1 Expression through Targeting ERα to Control Cell Proliferation in Breast Cancer American Journal of Pathology

How P, Shihab O, Tekkis P, Brown G, Quirke P, Heald R, Moran B. A systematic review of cancer related patient outcomes after anterior resection and abdominoperineal excision for rectal cancer in the total mesorectal excision era. Surg Oncol. [Epub ahead of print]

Hutchins G, Southward K, Handley K, Magill L, Beaumont C, Stahlschmidt J, Richman S, Chambers P, Seymour M, Kerr D, Gray R, Quirke P. Value of Mismatch Repair, KRAS, and BRAF Mutations in Predicting Recurrence and Benefits From Chemotherapy in Colorectal Cancer. 2011 J Clin Oncol 07 Mar.

Iris D. Nagtegaal, Quirke, P, Hans-Joachim Schmoll Has the new TNM classification for colorectal cancer improved care? Nat. Rev. Clin. Oncol.

Lyttleton O, Wright A, Treanor D, Quirke P, Lewis P. Extending the tissue microarray data exchange specification of data analysis results. 2011 J Path 2(1):17

Martijnse IS, Dudink RL, Kusters M, Vermeer TA, West NP, Nieuwenhuijzen GA, van Lijnschoten I, Martijn H, Creemers GJ, Lemmens VE, van de Velde CJ, Sebag-Montefiore D, Glynne-Jones R, Quirke P, Rutten HJ. T3+ and T4 Rectal Cancer Patients Seem to Benefit From the Addition of Oxaliplatin to the Neoadjuvant Chemoradiation Regimen. Ann Surg Oncol

Martijnse IS, Dudink RL, West NP, Wasowicz D, Nieuwenhuijzen GA, van Lijnschoten I, Martijn H, Lemmens VE, van de Velde CJ, Nagtegaal ID, Quirke P, Rutten HJ. Focus of Extralevator Perineal dissection in supine position for low rectal cancer has led to better quality of surgery and oncologic outcome. Surg Oncology

Mine S, Yamada K, Grabsch H, Sano T, Ishiyama A, Hirasawa T, Yamamoto N, Hiki N, Yamaguchi T. The Prognostic Significance of Tumor Laterality in Patients with Esophageal Squamous Cell Carcinoma. J Surgical Oncology

Morris EJ, Jordan C, Thomas JD, Cooper M, Brown JM, Thorpe H, Cameron D, Forman D, Jayne D, Quirke P; CLASICC trialists. Comparison of treatment and outcome information between a clinical trial and the National Cancer Data Repository. Br J Surg. 2011 Feb;98(2):299-307.

Morris EJ, Taylor EF, Thomas JD, Quirke P, Finan PJ, Coleman MP, Rachet B, Forman D. Thirty-day postoperative mortality after colorectal cancer surgery in England. Gut. 60(6):806-13. Epub 2011 Apr 12.

Nagtegall ID, Tot T, Jayne DG, McShane P, Nihlberg A, Marshall HC, Pahlman L, Brown JM, Guillou PJ, Quirke P. Lymph nodes, tumor deposits and TNM: are we getting better? 2011 J Clin Oncol

Patel UB, Taylor F, Blomqvist L, George C, Evans H, Tekkis P, Quirke P, Sebag-Montefiore D, Moran B, Heald R, Guthrie A, Bees N, Swift I, Pennert K, Brown G. Magnetic Resonance Imaging-Detected tumor response for locally advanced rectal cancer predicts survival outcomes: MERCUTY Experience Journal of Clinical Oncology

Peter MB, Shaaban AM, Rajan SS, Maraqa L, Horgan K, Speirs V Investigating and critically appraising the expression and potential role of androgen receptor in breast carcinoma. Hormone Molec Biol Clin Invest 2011; 7:273–278

Quirke P, Risio M, Lambert R, von Karsa L, Vieth M. Quality assurance in pathology in colorectal cancer screening and diagnosis—European recommendations. Virchows Arch. 2011 Jan;458(1):1-19

Richardson J, Shaaban AM, Kamal M, Alisary R, Ellis I, Speirs V, Green A, Bell SM Microcephalin is a new novel prognostic marker in breast cancer associated with BRCA1 inactivation. Breast Cancer Res Treat 2011; 127:639-648

Richman SD, Chambers P, Seymour MT, Daly C, Grant S, Hemmings G, Quirke P. Intra-tumoral heterogeneity of KRAS and BRAF mutation status in patients with advanced colorectal cancer (aCRC) and cost-effectiveness of multiple sample testing. 2011 Anal Cell Pathol 34(1):61-66

Roylance R, Endesfelder D, Gorman P, Burrell RA, Sander J, Tomlinson IP, Hanby AM, Speirs V, Richardson AL, Birkbak NJ, Eklund AC, Downward J, Szallasi Z, Kschischo M, Swanton C. Relationship of extreme chromosomal instability with superior long-term survival in a retrospective analysis of ER-negative primary breast cancer. Cancer Epidemiol Biomarkers Prev 2011; 20:2183-2194

Shihab OC, How P, West N, George C, Patel U, Quirke P, Heald RJ, Moran BJ, Brown G Can a Novel MRI staging System for Low Rectal Cancer Aid Surgical Planning? Dis Colon Rectum. 2011 Oct;54(10):1260-4.

Shihab OC, Taylor F, Salerno G, Heald RJ, Quirke P, Moran BJ, Brown G MRI Predictive Factors for Long-Term Outcomes of Low Rectal Tumours. Ann Surg Oncol. [Epub ahead of print]

Shinji M, Kazuhiko Y, Grabsch, H, Sano T, Ishiyama A, Hirasawa T, Yamamoto N, Hiki N, Yamaguchi T The prognostic significance of tumor laterality in patients with esophageal squamous cell carcinoma J Surg Oncol. 2011 Aug 12 doi 101.1002/jso.22069

Smith KJ, Jones PF, Burke DA, Treanor D, Finan PJ, Quirke P. Lymphatic vessel distribution in the mucosa and submucosa and potential implications for T1 colorectal tumors. 2011 Dis Colon Rectum 54(1):35-40.

Southward K, Hutchins G, Handley K, Magill L, Beaumont C, Stahlschmidt J, Richman S, Chambers P, Seymour M, Kerr D et al. B-raf mutation and mismatch repair deficiency are significantly correlated and both are commonly found in right-sided stage II colorectal cancers. 2011 J Path 224:s17-s17

Southward K, Hutchins G, Handley K, Magill L, Beaumont C, Stalhschmidt J, Richman S, Chambers P, Seymour M, Kerr D et al. 2011 J Path 224:s4-s4

Tan I, Ivanova T, Kiat HonLim, Chee Wee Ong, Deng N, Lee J, Sze Huey Tan, Wu J, Ming Hui Lee, Chia Huey Ooi, Sun Young Rha, Wai Keong Wong, Boussioutas A, Toh H, Rozen S, Cheong J, Noh S, Wan W, Ajani JA, Lee J-S, Grabsch H, Tan P. Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, predict survival and respond to chemotherapy. Gastroenterology 2011; 141:476-485

Taylor FG, Quirke P, Heald RJ, Moran B, Blomqvist L, Swift I, Sebag-Montefiore DJ, Tekkis P, Brown G; for the MERCURY study group. Preoperative High-resolution Magnetic Resonance Imaging Can Identify Good Prognosis Stage I, II, and III Rectal Cancer Best Managed by Surgery Alone: A Prospective, Multicenter, European Study That Recruited Consecutive Patients With Rectal Cancer. 2011 Ann Surg 253(4):711-719

Taylor FG, Quirke P, Heald RJ, Moran B, Blomqvist L, Swift I, St Rose S, Sebag-Montefiore DJ, Tekkis P, Brown G; on behalf of the MERCURY study group. One millimetre is the safe cut-off for magnetic resonance imaging prediction of surgical margin status in rectal cancer. Published online 8 April 2011 in Wiley Online Library DOI: 10.1002/bjs.7458

Tomlinson DC, Knowles MA, Speirs V Mechanisms of FGFR3 actions in endocrine resistant breast cancer. IJC

Verghese ET, Shenoy H, Cookson V, Green CA, Pollock S, Waterworth A, Speirs V, Hughes TA  Hanby AM Epithelial-mesenchymal interactions in breast cancer: evidence for a role of nuclear localised β-catenin in carcinoma-associated fibroblasts. Histopathol 2011; 59:609-618

Vieth M, Quirke P, Lambert R, von Karsa L, Risio M. Annex to Quirke et al. Quality assurance in pathology in colorectal cancer screening and diagnosis: annotations of colorectal lesions. Virchows Arch. 2011 Jan;458(1):21-30

West NP, Quirke P, Hagemann-Madsen RH. Close teamwork between pathologist and sugeon can improve results in colorectal cancer treatment. 2011 Ugeskr Laeger 173(14): 1037-1040

White J, Kearins O, Dodwell D, Horgan K, Hanby AM, Speirs V Male breast carcinoma - increased awareness needed. Breast Cancer Res 2011; 13:219-225

Wright A, Lyttleton O, Quirke P, Treanor D. The tissue microarray data exchange specification: extending TMA DES to provide flexible scoring and incorporate virtual slides. 2011 J Pathol Inform 2:15

2010 Publications

Alali L, Honarpisheh H, Shaaban AM, Speirs V Conditions of the male breast: gynaecomastia and male breast cancer. Mol Med Reports 2010 3: 21-26

Al-Nakhle H, Burns PA, Cummings M, Hanby AM, Hughes TA, Satheesha S, Shaaban AM, Smith L, Speirs V ERβ1 expression is regulated by miR-92 in breast cancer. Cancer Res 2010 70: 4778-4784

Brosens RP, Belt EJ, Haan JC, Buffart TE, Carvalho B, Grabsch H, Quirke P, Cuesta MA, Engel AF, Ylstra B, Meijer GA. Deletion of chromosome 4q predicts outcome in stage II colon cancer patients. Anal Cell Pathol (Amst). 2010;33(2):95-104.

Brosens RP, Haan JC, Carvalho B, Rustenburg F, Grabsch H, Quirke P, Engel AF, Cuesta MA, Maughan N, Flens M, Meijer GA, Ylstra B. Candidate driver genes in focal chromosomal aberrations of stage II colon cancer. J Pathol. 2010 Aug;221(4):411-24.

Canning S, Dye L, Ayres J, Orsi NM, Simpson NAB, Waterman M (2010) A randomised, double-blind, placebo-controlled trial to test the efficacy of Hypericum perforatum (St. John¹s Wort) for the treatment of premenstrual syndrome. CNS Drugs (in press)

Diosdado B, Buffart TE, Watkins R, Carvalho B, Ylstra B, Tijssen M, Bolijn AS, Lewis F, Maude K, Verbeke C, Nagtegaal ID, Grabsch H, Mulder CJ, Quirke P, Howdle P, Meijer GA. High-resolution array comparative genomic hybridization in sporadic and celiac disease-related small bowel adenocarcinomas. Clin Cancer Res. 2010 Mar 1;16(5):1391-401. Epub 2010 Feb 23.

Jayne DG, Thorpe HC, Copeland J, Quirke P, Brown JM, Guillou PJ. Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer. Br J Surg. 2010 Nov;97(11):1638-45.

Kamal M, Shaaban AM, Zhang L, Walker C, Gray S, Thakker N, Toomes C, Speirs V, Bell SM Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma. Breast Cancer Res Treat 2010 121: 555-563

Kerr D, O'Connell MJ, Lavery IC, Gray R, Yothers G, Quirke P, Lopatin M, Clark-Langone K, Lee M, Wolmark N Considerations in the developmen and validation of genomic tests for cancer recurrence and treatment benefit. Annals of Oncology 2010 21: 44-44.

Morris E, Birch R, West N, Finan P, Forman D, Fairley L, Quirke P. Low abdomino-perineal excision rates are associated with high workload surgeons and lower tumour height. Is further specialisation needed? Colorectal Dis. 2010 Mar 13. [Epub ahead of print]

Morris EJ, Forman D, Thomas JD, Quirke P, Taylor EF, Fairley L, Cottier B, Poston G. Surgical management and outcomes of colorectal cancer liver metastases. Br J Surg. 2010 Jul;97(7):1110-8.

Nagtegaal ID, Quirke P. Revised staging: is it really better, or do we not know? J Clin Oncol. 2010 Aug 10;28(23):e397-8; author reply e399-400. Epub 2010 Jun 14. No abstract available.

Quirke P, Cuvelier C, Ensari A, Glimelius B, Laurberg S, Ortiz H, Piard F, Punt CJ, Glenthoj A, Pennickx F, Seymour M, Valentini V, Williams G, Nagtegaal ID. Evidence-based medicine: the time has come to set standards for staging. J Pathol. 2010 Aug;221(4):357-60.

Richman SD, Hutchins GG, Seymour MT, Quirke P. What can the molecular pathologist offer for optimal decision making? Ann Oncol. 2010 Oct;21 Suppl 7:vii123-vii129.

Shihab OC, Quirke P, Heald RJ, Moran BJ, Brown G. Magnetic resonance imaging-detected lymph nodes close to the mesorectal fascia are rarely a cause of margin involvement after total mesorectal excision. Br J Surg. 2010 Sep;97(9):1431-6.

Smith L, Speirs V, Hughes TA Estrogen receptor regulation – don’t forget translation. Breast Cancer Res Treat 2010 121: 251-252

Speirs V, Pollock S, Shaaban AM, Hanby AM. Problems (and solutions) in the study of male breast cancer. Rare Tumors 2010 2:78

Stephens RJ, Thompson LC, Quirke P, Steele R, Grieve R, Couture J, Griffiths GO, Sebag-Montefiore D. Impact of short-course preoperative radiotherapy for rectal cancer on patients' quality of life: data from the Medical Research Council CR07/National Cancer Institute of Canada Clinical Trials Group C016 randomized clinical trial. J Clin Oncol. 2010 Sep 20;28(27):4233-9. Epub 2010 Jun 28.

West NP, Anderin C, Smith KJ, Holm T, Quirke P; European Extralevator Abdominoperineal Excision Study Group. Multicentre experience with extralevator abdominoperineal excision for low rectal cancer. Br J Surg. 2010 Apr;97(4):588-99.

West NP, Dattani M, McShane P, Hutchins G, Grabsch J, Mueller W, Treanor D, Quirke P, Grabsch H. The proportion of tumour cells is an independent predictor for survival in colorectal cancer patients. Br J Cancer. 2010 May 11;102(10):1519-23. Epub 2010 Apr 20.

West NP, Sutton KM, Ingeholm P, Hagemann-Madsen RH, Hohenberger W, Quirke P. Improving the quality of colon cancer surgery through a surgical education program. Dis Colon Rectum. 2010 Dec;53(12):1594-603.

2009 Publications

Belien JA, Buffart TE, Gill AJ, Broeckaert MA, Quirke P, Meijer GA, Grabsch HI. Gross genomic damage measured by DNA image cytometry independently predicts gastric cancer patient survival. Br J Cancer. 2009 Sep 15;101(6):1011-8.

Buffart TE, van Grieken NC, Tijssen M, Coffa J, Ylstra B, Grabsch HI, van de Velde CJ, Carvalho B, Meijer GA. High resolution analysis of DNA copy-number aberrations of chromosomes 8, 13, and 20 in gastric cancers. Virchows Arch. 2009 Sep;455(3):213-23. Epub 2009 Aug 21.

Cummings M, Iremonger, J, Green CA, Shaaban AM, Speirs V Gene expression of ERß isoforms in laser microdissected human breast cancers: implications for gene expression analyses. Cell Oncol 2009 31: 467-473

Charalambous MP, Lightfoot T, Speirs V, Horgan K, Gooderham NJ Expression of COX-2, NF-kβ-p65 and IKKα in malignant and adjacent normal human colorectal tissue. Br J Cancer 2009 101: 106-15

Coleman LJ, Peter MB, Teall TJ, Brannan RA, Hanby AM, Honarpisheh H, Shaaban AM, Smith L, Speirs V, Verghese ET, McElwaine JN, Hughes TA Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity. Br J Cancer 2009 100: 1393-1399

Gordon, A. J., Halliday, J. A., Blankschien, M. D., Burns, P. A., Yatagai, F., Herman, C. (2009). "Transcriptional infidelity promotes heritable phenotypic change in a bistable gene network." PLoS Biol 7(2): 0364-0370 (e1000044. doi:10.1371/journal.pbio.1000044)

Milne F, Redman C, Walker J, et al. Assessing the onset of pre-eclampsia in the hospital day unit: summary of the pre-eclampsia guideline (PRECOG II). BMJ. 2009;339:b3129.

Ooi CH, Ivanova T, Wu J, Lee M, Tan IB, Tao J, Ward L, Koo JH, Gopalakrishnan V, Zhu Y, Cheng LL, Lee J, Rha SY, Chung HC, Ganesan K, So J, Soo KC, Lim D, Chan WH, Wong WK, Bowtell D, Yeoh KG, Grabsch H, Boussioutas A, Tan P. Oncogenic pathway combinations predict clinical prognosis in gastric cancer. PLoS Genet. 2009 Oct;5(10):e1000676. Epub 2009 Oct 2.

Quirke P, Steele R, Monson J, Grieve R, Khanna S, Couture J, O'Callaghan C, Myint AS, Bessell E, Thompson LC, Parmar M, Stephens RJ, Sebag-Montefiore D; MRC CR07/NCIC-CTG CO16 Trial Investigators; NCRI Colorectal Cancer Study Group. Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial. Lancet. 2009 Mar 7;373(9666):821-8.

Turner E, Brewster JA, Simpson NA, Walker JJ, Fisher J. Imidazole-Based Erythrocyte Markers of Oxidative Stress in Preeclampsia: An NMR Investigation. Reprod Sci. Aug 5 2009.

West NP, Weber K,Perrakis A, Finan P,Hohenberger W, Quirke P. Complete mesocolic excision with central vascular ligation is oncologically superior to standard surgery for carcinoma of the colon. JCO on line10.1200/JCO.2009.24.1448

2008 Publications

Allan, J.M; Shorto, J; Adlard, J; Bury, J; Coggins, R; George, R; Katory, M; Quirke, P; Richman, S; Scott, D; Scott, K; Seymour, M; Travis, L.B; Worrillow, L.J; Bishop, D.T; Cox, A; UK NCRI Colorectal Clinical Studies Group; Colorectal Cancer Study Group. MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer. Int J Cancer 123(10):2456-9

Brewster, J.A; Orsi, N.M; Gopichandran, N; Ekbote, U.V; Cadogan, E; Walker, J.J. 2008 Host inflammatory response profiling in preeclampsia using an in vitro whole blood stimulation model. Hypertens Pregnancy 27(1):1-16

Brewster, J.A; Orsi, N.M; Gopichandran, N; McShane, P; Ekbote, U.V; Walker, J.J. 2008 Gestational effects on host inflammatory response in normal and pre-eclamptic pregnancies. Eur J Obstet Gynecol Reprod Biol 140(1):21-26

Braun, M.S; Richman, S.D; Quirke, P; Daly, C; Adlard, J.W; Elliott, F; Barrett, J.H; Selby, P; Meade, A.M; Stephens, R.J; Parmar, M.K; Seymour, M.T. 2008 Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. J Clin Oncol 26(16):2690-8

Buffart, T.E; Overmeer, R.M; Steenbergen, R.D; Tijssen, M; van Grieken, N.C; Snijders, P.J; Grabsch, H.I; van de Velde, C.J; Carvalho, B; Meijer, G.A. 2008 MAL promoter hypermethylation as a novel prognostic marker in gastric cancer. Br J Cancer 99(11):1802-1807

Chaparala, R.P; Orsi, N.M; Lindsey, N.J; Girn, H.R; Homer-Vanniasinkam, S. 2008 Inflammatory Profiling of Peripheral Arterial Disease. Ann Vasc Surg. Jul 26. [Epub ahead of print]

Dowsett, M; Allred, C; Knox, J; Quinn, E; Salter, J; Wale, C; Cuzick, J; Houghton, J; Williams, N; Mallon, E; Bishop, H; Ellis, I; Larsimont, D; Sasano, H; Carder, P; Cussac, A.L; Knox, F; Speirs, V; Forbes, J; Buzdar, A 2008 Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the Arimidex, Tamoxifen, Alone or in Combination trial. J Clin Oncol 26: 1059-1065

Fraser, R; Walker, J.J; Ekbote, U.V; Martin, K.L; McShane, P; Orsi, N.M. 2008 Interleukin-4 -590 (C>T), toll-like receptor-2 +2258 (G>A) and matrix metalloproteinase-9 -1562 (C>T) polymorphisms in pre-eclampsia. BJOG 115(8):1052-1056

Ganesan, K; Ivanova, T; Wu, Y; Rajasegaran, V; Wu, J; Lee, M.H; Yu, K; Rha, S.Y; Chung, H.C; Ylstra, B; Meijer, G; Lian, K.O; Grabsch, H; Tan, P. Inhibition of gastric cancer invasion and metastasis by PLA2G2A, a novel beta-catenin/TCF target gene. Cancer Res 68(11):4277-4286

Green, C.A; Peter, M.B; Speirs, V; Shaaban, A.M 2008 The potential role of ERβ isoforms in the clinical management of breast cancer. Histopatol 53: 374-80

Hanby, A,M; Hughes, T.A. 2008 In situ and invasive lobular neoplasia of the breast. Histopathology 52:58-66

Hou, Q; Wu, Y.H; Grabsch, H; Zhu, Y; Leong, S.H; Ganesan, K; Cross, D; Tan, L.K; Tao, J; Gopalakrishnan, V; Tang, B.L; Kon, O.L; Tan, P. 2008 Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer. Cancer Res 68(12):4623-4630

Johnson, N; Speirs, V; Curtin, N.J; Hall, A.G 2008 A comparative study of genome-wide SNP, CGH microarray and protein expression analysis to explore genotypic and phenotypic mechanisms of acquired antiestrogen resistance in breast cancer. Breast Cancer Res Treat 111: 55-63

Jones, A.M; Mitter, R; Poulsom, R; Gillett, C; Hanby, A.M; Tomlinson, I.P; Sawyer, E.J. 2008a mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours. J Pathol 216:408-17

Jones, A.M; Mitter, R; Springall, R; Graham, T; Winter, E; Gillett, C; Hanby, A.M; Tomlinson, I.P; Sawyer, E.J. 2008b A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence. J Pathol 214: 533-44

Ko, C.W; Cuthbert, R.J; Orsi, N.M; Brooke, D.A; Perry, S.L; Markham, A.F; Coletta, P.L; Hull, M.A. 2008 Lack of interleukin-4 receptor alpha chain-dependent signalling promotes azoxymethane-induced colorectal aberrant crypt focus formation in Balb/c mice. J Pathol 214(5):603-9

Lewis, P.D; Manshian, B; Routledge, M.N; Scott, G.B; Burns, P.A. 2008 Comparison of induced and cancer-associated mutational spectra using multivariate data analysis. Carcinogenesis 29:772-8

Maraqa, L; Cummings, M; Peter, M.B; Shaaban, A.M; Horgan, K; Hanby, A.M; Speirs, V 2008 Carcinoembryonic antigen cell adhesion molecule 6 predicts breast cancer recurrence following adjuvant tamoxifen. Clin Cancer Res 14: 405-411

Morris, E; Quirke, P; Thomas, J.D; Fairley, L; Cottier, B; Forman, D. 2008 Unacceptable variation in abdominoperineal excision rates for rectal cancer: time to intervene? Gut 57(12):1690-1697

Nagtegaal, I.D; Quirke, P 2008 What Is the Role for the Circumferential Margin in the Modern Treatment of Rectal Cancer? J Clin Oncol 26:303-312

Nguyen Huu, N.S; Ryder, W.D; Zeps, N; Flasza, M; Chiu, M; Hanby, A.M; Poulsom, R; Clarke, R.B; Baron, M. 2008 Tumour-promoting activity of altered WWP1 expression in breast cancer and its utility as a prognostic indicator. J Pathol 216: 93-102

Orsi, N.M. 2008 Cytokine networks in the establishment and maintenance of pregnancy. Hum Fertil (Camb) 11(4):222-30

Orsi, N.M; Tribe, R.M. 2008 Cytokine networks and the regulation of uterine function in pregnancy and parturition. J Neuroendocrinol 20(4):462-9

Pipkin, F.B. 2008 Smoking in moderate/severe preeclampsia worsens pregnancy outcome, but smoking cessation limits the damage. Hypertension 51(4):1042-6

Robson, A; Lazar, A.J; Ben Nagi, J; Hanby, A; Grayson, W; Feinmesser, M; Granter, S.R; Seed, P; Warneke, C.L; McKee, P.H; Calonje, E. 2008 Primary cutaneous apocrine carcinoma: a clinico-pathologic analysis of 24 cases. Am J Surg Pathol 32: 682-90

Savage, K.J; Harris, N.L; Vose, J.M; Ullrich, F; Jaffe, E.S; Connors, J.M; Rimsza, L; Pileri, S.A; Chhanabhai, M; Gascoyne, R.D; Armitage, J.O; Weisenburger, D.D. 2008 International Peripheral T-Cell Lymphoma Project. ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project. Blood 111(12):5496-504

Shaaban, A.M; Green, A.R; Karthik, S; Alizadeh, Y; Hughes, T.A; Harkins, L; Ellis, I.O; Robertson, J.F; Paish, E.C; Saunders, P.T.K; Groome, N.P; Speirs, V 2008 Nuclear and cytoplasmic expression of ERβ1, -2 and -5 identifies distinct prognostic outcome for breast cancer patients. Clin Cancer Res 14: 5228-35

Shihab, O.C; Moran, B.J; Heald, R.J; Quirke, P; Brown, G. 2008 MRI staging of low rectal cancer Eur Radiol Sep 23 Speirs, V; Green, A.R; Hughes, T.A; Ellis, I.O; Saunders, P.T.K; Shaaban, A.M 2008 Clinical importance of estrogen receptor β isoforms in breast cancer. J Clin Oncol 26:5825-5826

Simon, M; Duong, J.P; Mallet, V; Jian, R; MacLennan, K.A; Sandle, G.I; Marteau, P. 2008 Over-expression of colonic K+ channels associated with severe potassium secretory diarrhoea after haemorrhagic shock. Nephrol Dial Transplant 3(10):3350-2

Speirs, V; Green, A.R; Hughes, T.A; Ellis, I.O; Saunders, P.T.K; Shaaban, A.M. 2008 Clinical importance of estrogen receptor β isoforms in breast cancer. J Clin Oncol 26:5825-5826

Speirs, V. 2008 The evolving role of estrogen receptor β in clinical breast cancer. Breast Cancer Res 10: 111-112 Speirs, V; Green, C.A; Shaaban, A.M. 2008 Oestrogen receptor β immunohistochemistry – time to get it right? J Clin Path 61:1150-1151

Thomas, J; Hanby, A; Pinder, S; Ellis, I; Macartney, J; Clements, K; Lawrence, G; Bishop, H. 2008 Implications of inconsistent measurement of ER status in non-invasive breast cancer: a study of 1,684 cases from the Sloane Project. Breast J 14: 33-8

Thorpe, H; Jayne, D.G; Guillou, P.J; Quirke, P; Copeland, J; Brown, J.M; Medical Research Council Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer Trial Group. 2008 Patient factors influencing conversion from laparoscopically assisted to open surgery for colorectal cancer. Br J Surg 95(2):199-205

Turner, S; Derham, C; Orsi, N.M; Bosomworth, M; Bellamy, M.C; Howell, S.J. 2008 Randomized clinical trial of the effects of methylprednisolone on renal function after major vascular surgery. Br J Surg 95(1):50-6

Turner, E; Brewster, J.A; Simpson, N.A; Walker, J.J; Fisher, J. 2008 Aromatic amino acid biomarkers of preeclampsia--a nuclear magnetic resonance investigation. Hypertens Pregnancy 27(3):225-35

van Krieken, J.H; Jung, A; Kirchner, T; Carneiro, F; Seruca, R; Bosman, F.T; Quirke, P; Fléjou, J.F; Plato Hansen, T; de Hertogh, G; Jares, P; Langner, C; Hoefler, G; Ligtenberg, M; Tiniakos, D; Tejpar, S; Bevilacqua, G; Ensari, A. 2008 KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program. Virchows Arch. 453(5):417-31

Verghese, E.T; Hanby, A.M; Speirs, V; Hughes, T.A 2008 Small is beautiful: microRNAs and breast cancer - where are we now? J Pathol 215: 214-221

Walker, R.A; Bartlett, J.M; Dowsett, M; Ellis, I.O; Hanby, A.M; Jasani, B; Miller, K; Pinder, S.E 2008 HER2 testing in the UK: further update to recommendations. J Clin Pathol 61: 818-24

Webster, L.R; Lee, S.F; Ringland, C; Morey, A.L; Hanby, A.M; Morgan, G; Byth, K; Mote, P.A; Provan, P.J; Ellis, I.O; Green, A.R; Lamoury, G; Ravdin, P; Clarke, C.L; Ward, R.L; Balleine, R.L; Hawkins, N.J. 2008 Poor-prognosis estrogen receptor-positive breast cancer identified by histopathologic subclassification. Clin Cancer Res 14: 6625-33

West, N.P; Morris, E.J; Rotimi, O; Cairns, A; Finan, P.J; Quirke, P. 2008 Pathology grading of colon cancer surgical resection and its association with survival: a retrospective observational study. Lancet Oncol 9(9):857-65

West, N.P; Finan, P.J; Anderin, C; Lindholm, J; Holm, T; Quirke P. 2008 Evidence of the oncologic superiority of cylindrical abdominoperineal excision for low rectal cancer. J Clin Oncol 26(21):3517-22

2007 Publications

Bradley, P.J; MacLennan, K; Brakenhoff, R.H; Leemans, C.R 2007 Status of primary tumour surgical margins in squamous head and neck cancer: prognostic implications. Curr Opin Otolaryngol Head Neck Surg Apr;15(2):74-81.

Braun, M.S; Quirke, P; Seymour, M.T 2007 Molecular markers of chemotherapeutic response and toxicity in colorectal cancer. Expert Rev Anticancer Ther Apr;7(4):489-501

Brooke, D.A; Orsi, N.M; Ainscough, J.F; Holwell, S.E; Markham, A.F; Coletta, P.L. 2007 Human menopausal and pregnant mare serum gonadotrophins in murine superovulation regimens for transgenic applications. Theriogenology 67(8):1409-1413

Buffart, T.E; Tijssen, M; Krugers, T; Carvalho, B; Smeets, S.J; Brakenhoff, R.H; Grabsch, H; Meijer, G.A; Sadowski, H.B; Ylstra, B 2007 DNA quality assessment for array CGH by isothermal whole genome amplification. Cell Oncol 29(4):351-9.

Chapple, K.S; Parry, D.J; McKenzie, S; MacLennan, K.A; Jones, P; Scott, D.J 2007 Cyclooxygenase-2 expression and its association with increased angiogenesis in human abdominal aortic aneurysms. Ann Vasc Surg Jan;21(1):61-6

Cockle, J.V; Gopichandran, N; Walker, J.J; Levene, M.I; Orsi, N.M. 2007 Matrix metalloproteinases and their tissue inhibitors in preterm perinatal complications. Reprod Sci 14(7):629-645

Dowsett, M; Hanby, A.M; Laing, R; Walker, R 2007 HER-2 testing in the UK: consensus from a national consultation. Journal of Clinical Pathology 60(6):685-9

Fulford, L.G; Reis-Filho, J.S; Ryder, K; et al. 2007 Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival. Breast Cancer Research 9:R4

Girn, H.R; Orsi, N.M; Homer-Vanniasinkam, S. 2007 An overview of cytokine interactions in atherosclerosis and implications for peripheral arterial disease. Vasc Med 12(4):299-309

GOPEC-consortium. 2007 Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study. J Hypertens 25(4):849-54

Gottschalg, E; Scott, G.B; Burns, P.A; Shuker, D.E 2007 Potassium diazoacetate-induced p53 mutations in vitro in relation to formation of O6-carboxymethyl- and O6-methyl-2'-deoxyguanosine DNA adducts: relevance for gastrointestinal cancer. Carcinogenesis Feb;28(2):356-62.

Greetham, H.L; Bingham, S.A; Burns, P.A 2007 Adduction of human p53 gene by fecal water: an in vitro biomarker of mutagenesis in the human large bowel. Cancer Epidem. Biomar (in press)

Griffiths, J.A; Royle, G.J; Hanby, A.M; Horrocks, J.A; Bohndiek, S.E; Speller, R.D 2007 Correlation of energy dispersive diffraction signatures and microCT of small breast tissue samples with pathological analysis. Phys Med Biol Oct 21;52(20):6151-64.

Hamilton, S; Hepper, J; Hanby, A; Hewison, J 2007 Consent gained from patients after breast surgery for the use of surplus tissue in research: an exploration. J Med Ethics 33:229-33

Holton, C; Cruickshank, H.E; High, A.S; Maclennan, K; Makura, Z.G 2007 Paediatric granular cell tumour of the larynx: case report of laser resection with frozen section. J Laryngol Otol May;121(5):506-9.

Hopkins, T.G; Burns, P.A; Routledge, M.N 2007 DNA methylation of GSTP1 as a biomarker in the diagnosis of prostate cancer. Urology 69: 11-16.

Jayne, D.G; Guillou, P.J; Thorpe, H; Quirke, P; Copeland, J; Smith, A.M; Heath, R.M; Brown, J.M; UK MRC CLASICC Trial Group 2007 Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group. J Clin Oncol Jul 20;25(21):3061-8.

Jong, K; Marchiori, E; van der Vaart, A; Chin, S.F; Carvalho, B; Tijssen, M; Eijk, P.P; van den Ijssel, P; Grabsch, H; Quirke, P; Oudejans, J.J; Meijer, G.A; Caldas, C; Ylstra, B 2007 Cross-platform array comparative genomic hybridization meta-analysis separates hematopoietic and mesenchymal from epithelial tumors. Oncogene Mar 1;26(10):1499-506.

Masannat, Y.A; Shaaban, A.M; Speirs, V; Coast, G; Jackson, P; Horgan, K; Hanby, A.M 2007 Adverse effects of dyes used in sentinel node biopsy on immunocytochemical determination of hormone receptors in breast cancer cells. J Clin Pathol Jun;60(6):730-2.

Matthews, C.E; Wilcox, S; Hanby, C.L; Der Ananian, C; Heiney, S.P; Gebretsadik, T; Shintani, A. 2007 Evaluation of a 12-week home-based walking intervention for breast cancer survivors. Support Care Cancer 15: 203-211

Maughan, N.J; Morris, E; Forman, D; Quirke, P 2007 The validity of the Royal College of Pathologists' colorectal cancer minimum dataset within a population. Br J Cancer Nov 19;97(10):1393-8

Menzies, J; Magee, L.A; Macnab, Y.C; Ansermino, J.M; Li, J; Douglas, M.J; et al. 2007 Current CHS and NHBPEP Criteria for Severe Preeclampsia Do Not Uniformly Predict Adverse Maternal or Perinatal Outcomes. Hypertens Pregnancy 26(4):447-62

Moran, B; Brown, G; Cunningham, D; Daniels, I; Heald, R; Quirke, P; Sebag-Montefiore, D 2007 Clarifying the TNM staging of rectal cancer in the context of modern imaging and neo-adjuvant treatment: 'y''u' and 'p' need 'mr' and 'ct' Colorectal Dis May 10;

Morris, E.J; Maughan, N.J; Forman, D; Quirke, P 2007 Identifying stage III colorectal cancer patients: the influence of the patient, surgeon, and pathologist. J Clin Oncol Jun 20;25(18):2573-9.

Morris, E.J; Maughan, N.J; Forman, D; Quirke, P 2007 Who to treat with adjuvant therapy in Dukes B/stage II colorectal cancer? The need for high quality pathology. Gut Oct;56(10):1419-25.

Nagtegaal, I.D; Quirke, P 2007 Colorectal tumour deposits in the mesorectum and pericolon; a critical review. Histopathology Aug;51(2):141-9

Orsi, N.M; Ekbote, U.V; Walker, J.J; Gopichandran, N. 2007 Uterine and serum cytokine arrays in the mouse during estrus. Anim Reprod Sci 100(3-4):301-310

Orsi, N.M; Gopichandran, N; Simpson, N.A. 2007 Genetics of preterm labour. Best Pract Res Clin Obstet Gynaecol 21(5):757-72.

Orsi, N.M; Gopichandran, N; Bulsara, H; Ekbote, U.V; Walker, J.J. 2007 Regulation of maternal serum and amniotic fluid cytokine profiles in the mouse: possible roles in the onset of labour. J Reprod Immunol 75(2):97-105

Orsi, N.M; Reischl, J.B 2007 Mammalian embryo co-culture: Trials and tribulations of a misunderstood method. Theriogenology 67:441-458

Perry, S.E; Robinson, P; Melcher, A; Quirke, P; Buhring, H-J; Cook, G.P; Blair, G.E 2007 Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells. FEBS letters 581:1137-1142

Quirke, P; Morris, E 2007 Reporting colorectal cancer. Histopathology Oct;51(4):555-6

Quirke, P; Williams, G.T; Ectors, N; Ensari, A; Piard, F; Nagtegaal, I 2007 The future of the TNM staging system in colorectal cancer: time for a debate? Lancet Oncol Jul;8(7):651-7

Sandle, G.I; Perry, M.D; Mathialahan, T; Linley, J.E; Robinson, P; Hunter, M; MacLennan, K.A 2007 Altered cryptal expression of luminal potassium (BK) channels in ulcerative colitis. J Pathol May;212(1):66-73.

Scott, D.J; Parkes, A.T; Ponchel, F; Cummings, M; Poola, I; Speirs, V 2007 Changes in expression of steroid receptors, their downstream target genes and their associated co-regulators during the sequential acquisition of tamoxifen resistance in vitro. Int J Oncol Sep;31(3):557-65

Speirs, V; Shaaban, A.M 2007 Hormone receptors in defining breast cancer prognosis - time for a rethink? Nat Clin Pract Oncol 4:204-205

Speirs, V; Walker, R.A 2007 New perspectives into the biological and clinical relevance of oestrogen receptors in the human breast. J Pathol 211:499-506

Terry, G; Ho, L; Londesborough, P; Duggan, C; Hanby, A; Cuzick, J 2007 The expression of FHIT, PCNA and EGFR in benign and malignant breast lesions. Br J Cancer 96110-117

Thorpe, H; Jayne, D.G; Guillou, P.J; Quirke, P; Copeland, J; Brown, J.M; for the Medical Research Council Conventional versus Laparoscopic‐Assisted Surgery In Colorectal Cancer Trial Group 2007 Patient factors influencing conversion from laparoscopically assisted to open surgery for colorectal cancer. Br J Surg Aug 15

Treanor, D; Quirke, P 2007 Pathology of colorectal cancer. Clin Oncol (R Coll Radiol) Dec;19(10):769-76

Turner, E; Brewster, J.A; Simpson, N.A; Walker, J.J; Fisher, J. 2007 Plasma from women with preeclampsia has a low lipid and ketone body content--a nuclear magnetic resonance study. Hypertens Pregnancy 26(3):329-42

Walker, J.J. 2007 Ectopic pregnancy. Clin Obstet Gynecol 50(1):89-99

Wheeler, J; Agarwal, M; Sugden, J; Bladon, M; Quirke, P 2007 Experiences from the front-line routine consenting of surplus surgically removed tissue: without investment by the National Health Service fully informed consent for all is not available. J Clin Pathol Apr;60(4):351-4

Wright, A; Walker, J. 2007 Management of women who use drugs during pregnancy. Semin Fetal Neonatal Med 12(2):114-118

Papers in Press

Speirs, V; Shaaban, A.M 2008 The rising incidence of male breast cancer. Breast Cancer Res Treat, in press