Studentships are available from October 2010 for a fixed term of 3 years. Each studentship will fund EU/Home studentship fees, a stipend at MRC rate and laboratory consumables. Non–EU applicants would be required to obtain additional funding to cover the overseas component of the registration fee.
Applicants should have, or be expecting to obtain, a relevant first degree at a standard of 2:1 or above and are encouraged to contact the appropriate supervisor to discuss the project before submitting their application for the 4th Jan 2010 closing date.
Applicants are requested to consider the 15 projects outlined below and indicate an interest in up to 3 projects in a covering application letter.
Candidates invited to attend the interview day, on the 29th January 2010, will have the opportunity to meet supervisors and to discuss projects in more detail. Candidates will also be shown round LIMM facilities and meet staff from the Sections. Candidates invited for interview will be informed by 15th January 2010.
Further information for LIMM Postgraduate Research Students can be found at: http://www.limm.leeds.ac.uk/students.htm and http://www.limm.leeds.ac.uk/research.htm
Applications should include a covering letter choosing up to 3 projects the applicant may want to be considered for, a full CV and full details of 2 academic referees.
These should be sent or emailed to: Dr Rashida Anwar, Lead Postgraduate Tutor, Leeds Institute of Molecular Medicine, Level 9, Wellcome Trust Brenner Buidling, St James’s University Hospital, Beckett Street, Leeds LS9 7TF (tel no. 0113 2065645) email: r.anwar@leeds.ac.uk
Project 1: Statistical identification and analysis of pathways involved in melanoma susceptibility and prognosis
Project 2: Identifying genetic association with disease when sampling from multiple populations
Project 3: IKKα recruitment at NF-kappaB-dependent loci and alteration of chromatin organisation
Project 4: Interfering with a transcriptional master regulator to understand molecular function and validate a novel therapeutic target
Project 5: Role of Wnt signalling in the metastatic potential of ESFT
Project 6: Sticking peptides on protein interfaces: Developing a new, knowledge-based computational tool to design peptides for modulating protein-protein interactions
Project 7: Investigation of alternative therapy targets in LMO2-dependent cancer
Project 8: Identification of recessive disease genes in consanguineous families
Project 9: Helicobacter pylori associated mutations in gastric carcinogenesis
Project 10: A novel strategy for therapeutic targeting of cyclooxygenase-2 gene regulation in colon cancer
Project 11: Identification of soluble and genetic biomarkers of response to conventional and biological therapy in rheumatoid arthritis
Project 12: Understanding the immunological contribution towards the development of early Rheumatoid Arthritis
Project 13: Proteomic determination of predictive biomarkers for tyrosine kinase inhibitor therapy
Project 14: Investigation of cancer stem cells in leukaemia and ovarian cancer
Project 15: Does Parkin regulate mitochondrial transport in neurons?
Project 16: The regulation of epithelial-mesenchymal transition in gastric cancer
Project 17: Development of an organotypic model of the normal breast: A tool to investigate breast cancer initiation and progression
Project 18: An in vitro study of the effect of anaesthetic agents on macrophage function: implications for cancer recurrence
Project 19: The PDH/PDK system: a metabolic target for cancer therapy
For a downloadable pdf of all projects click here.